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In 2002, the G8 Global Partnership began as a 10-year, $20 billion initiative to prevent terrorists or states that support them from acquiring or developing weapons of mass destruction. The United States pledged $10 billion of that total. The U.S. Government participates in GP-related activities through programs at the Department of Defense, Department of Energy, Department of State, and other related agencies, and includes work in securing and dismantling fissile materials and nuclear weapons, promoting WMD export controls, destroying chemical weapons, aiding in WMD scientist redirection, and industry engagement, among other things.
The following U.S. programs have been involved in Global Partnership activities from 2002-2012:

Department of State

Department of Energy

Department of Defense

Other U.S. Government Departments