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The Bureau of International Security and Nonproliferation (ISN) is responsible for managing a broad range of U.S. nonproliferation polices, programs, agreements, and initiatives. The proliferation of Weapons of Mass Destruction (WMD) and related materials, technologies, and expertise -- and the fact that terrorists are trying to acquire them -- is a preeminent challenge to American national security. Combating this threat through bilateral and multilateral diplomacy is one of the highest priorities of the Department of State. The ISN Bureau leads the Department’s efforts to prevent the spread of WMD -- whether nuclear, biological, chemical, or radiological -- and their delivery systems.

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"“We must recommit ourselves to strengthening the three pillars of the nonproliferation regime. And with respect to those three pillars – nuclear disarmament, access to civilian nuclear energy, and nonproliferation – this Administration, the United States has led through deeds, not simply through words.”

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