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The Bureau of International Security and Nonproliferation (ISN) is responsible for managing a broad range of U.S. nonproliferation polices, programs, agreements, and initiatives. The proliferation of Weapons of Mass Destruction (WMD) and related materials, technologies, and expertise -- and the fact that terrorists are trying to acquire them -- is a preeminent challenge to American national security. Combating this threat through bilateral and multilateral diplomacy is one of the highest priorities of the Department of State. The ISN Bureau leads the Department’s efforts to prevent the spread of WMD -- whether nuclear, biological, chemical, or radiological -- and their delivery systems.

Video Remarks on the ISN Bureau Webpage

Assistant Secretary Countryman: "Here at the I-S-N bureau, our primary mission is to prevent the spread of weapons of mass destruction, their delivery systems, destabilizing conventional weapons, and related technologies. It’s hard to pick up a newspaper and not see some issue where the bureau has a role." Full Text»

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"“We must recommit ourselves to strengthening the three pillars of the nonproliferation regime. And with respect to those three pillars – nuclear disarmament, access to civilian nuclear energy, and nonproliferation – this Administration, the United States has led through deeds, not simply through words.”

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